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AG-1031 induced autophagic cell death and apoptosis in C6 glioma cells associated with Notch-1 s
Glioma is the most common primary brain tumor with high morbidity and poor prognosis. The effect of AG-1031, which is developed as an a
Identification and characterization of the potential promoter regions of 1031 kinds of human gen
To understand the mechanism of transcriptional regulation, it is essential to identify and characterize the promoter, which is located
Application of ProTide technology to gemcitabine: a successful approach to overcome the key canc
Gemcitabine is a nucleoside analogue commonly used in cancer therapy but with limited efficacy due to a high susceptibility to cancer c
Tumor necrosis factor‐alpha gene (TNF‐α) −1031/−863, −857 single‐nucleotide polymor
Abstract Objectives: Tumour necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β) participate in the establishment of inflam
TNF‐α gene 1031 T/C polymorphism in Turkish patients with Behçet's disease
Summary Background  Genetic factors that predispose individuals to Behçet's disease (BD) are considered to play an important role in
A Phase Ib Study of NUC-1031 in Combination with Cisplatin for the First-Line Treatment of Patie
BACKGROUNDCisplatin/gemcitabine is standard first-line treatment for patients with advanced biliary tract cancer (ABC). NUC-1031 (phosp
NUC-1031, use of ProTide technology to circumvent gemcitabine resistance: current status in clin
BackgroundResistance to gemcitabine chemotherapy is common in patients with pancreatic ductal adenocarcinoma (PDAC), biliary tract canc
Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: result
BACKGROUNDGemcitabine is used to treat a wide range of tumours, but its efficacy is limited by cancer cell resistance mechanisms. NUC-1
The promoter -1031(T/C) polymorphism in <it>tumor necrosis factor-alpha </it>associated with pol
Abstract Background A <it>tumor necrosis factor-alpha </it>is a multifunctional pro-inflammation cytokine, which has been considered as
LX‐1031, a tryptophan 5‐hydroxylase inhibitor, and its potential in chronic diarrhea associa
Abstract  LX‐1031 is an oral, small molecule tryptophan 5‐hydroxylase (TPH) inhibitor that reduces serotonin (5‐HT) synthesis p
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